University of Glasgow
School of Chemistry,
Joseph Black Building
Glasgow, G12 8QQ
e: klaas.wynne glasgow.ac.uk
t: +44 (141) 330 8522
lab: +44 (141) 330 7680/7678
Mrs Alexis J Stevenson
e: Alexis.Stevenson glasgow.ac.uk
t: +44 (141) 330 2529
In the ultrafast group (part of the Dynamics & Structure grouping), we are interested in the structure and dynamics of liquids and solutions. We study peptides, proteins, and other biomolecules but consider them as amorphous blobs that behave much like liquids. We are especially interested in phase behaviour such as supercooling of liquids, folding transitions in peptides, nucleation of crystals from solution, and liquid-liquid and liquid-crystalline transitions.
These phenomena are studied with a range of techniques. Obviously (it is the ‘ultrafast’ group after all), femtosecond laser techniques are used, especially a technique called optical Kerr-effect (OKE) spectroscopy. Using OKE, we can probe the dynamics of molecules in disordered matter from about 15fs to nanoseconds and beyond. This covers motions from fast vibrations, librations, and cage rattling, through to molecular diffusion. The temperature dependent behaviour of these processes tells us about the underlying supramolecular structure and molecular complexity.
In the last few years, we have become especially excited by molecular-scale structure growing visible, literally. An example is the nucleation of crystals from solution: such crystals start life as nanometre scale molecular clusters that, through chance, grow to become macroscopic crystals. Phase transitions in the liquid also start on a molecular scale and grow to cause separation of phases. Understanding these phenomena is both basic science and of huge commercial importance.
Thus, we are now expanding into exciting new experimental areas such as microscopy. With a brand new confocal fluorescence microscope, we will be able to study phase separation directly. Fluorescence lifetime imaging (FLIM) and fluorescence correlation spectroscopy (FCS) will give unique insight in the local properties of phases and the local molecular dynamics. Dynamic and static light scattering is used to follow the generation of clusters, droplets, and crystals as a function of time. Microfluidics will be used to carry out complex phase transitions and chemical reactions right under the microscope. Last but not least, we aim to control chemical matter: by using femtosecond lasers we should be able to push transitions around to a desired state.
The group has a large number of national and international collaborators. These collaborators help with the theoretical description of the experiments or add experimental techniques to our arsenal such as other spectroscopies, neutron and x-ray scattering, chemical synthesis, etc. Finally, we are organising international scientific conferences such as the Ultrafast Chemical Physics meetings (last one UCP2011) and the RSC Faraday Discussion meeting on ‘Mesostructure and Dynamics in Liquids and Solutions’ scheduled for Bristol (18-20 Sep 2013).
Animation of a liquid-liquid transition in triphenyl phosphite (TPP) taking place through nucleation as observed through phase-contrast microscopy. 1280 pixel version. (Joanna Mosses, 2011)
Image of triphenyl phosphite (TPP) crystals growing in the supercooled phase (photo Joanna Mosses, 2010). This is part of our studies of liquid-liquid phase transitions and crystal nucleation.
Nematic liquid crystalline phase of 5CB (35.4 C)
PhD studentship in crystal nucleation Glasgow University
A 4-year PhD studentship position is available for a EU resident to study crystal nucleation with a range of techniques in the DTC associated with the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation. The chemical physics of crystal nucleation is of great fundamental and practical importance but is yet poorly understood. It is therefore one of the grand challenges on the border between physics, chemistry, and chemical engineering. Crystallisation is supposed to occur according to the Gibbs mechanism where numerous pre-nuclei form and disappear until one of these becomes critical and continues to grow to form a macroscopic crystal. However, there is increasing evidence for non-classical (non Gibbs) nucleation of crystals.
We will apply a number of experimental techniques to elucidate early nucleation phenomena. These include femtosecond optical Kerr effect (OKE) spectroscopy, femtosecond IR pump-probe and 2D-IR spectroscopy, light scattering, Raman microscopy, and confocal fluorescence microscopy (including fluorescence lifetime imaging). Some of this work will be carried out by two postdocs in the group. We are now looking for a PhD student to complement this work focussing either on the ultrafast or the microscopy experiments depending on preference and experience.
For informal inquiries, please contact Klaas Wynne. For formal application please visit http://www.gla.ac.uk/colleges/scienceengineering/graduateschool/. More information on the ultrafast group at http://www.chem.gla.ac.uk/staff/wynne/ and http://www.ultrachemphys.org/. More information on the Dynamics & Structure “super” group at http://www.gla.ac.uk/schools/chemistry/research/ds/. See also the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation.
Fully funded PhD studentships in the Wynne group
University of Glasgow - School of Chemistry
See http://www.chem.gla.ac.uk/staff/wynne/ and: http://www.gla.ac.uk/schools/chemistry/research/ds/
Start date: summer 2012; duration: 3 years
Applications are invited for a number of PhD studentships in the Wynne group, which is part of the ‘Dynamics & Structure’ grouping at the University of Glasgow. Some of these studentships are part of the Doctoral Training Centre (DTC) in Continuous Manufacturing and Crystallisation (CMAC). A number of possible project titles are listed below with relevant skills and training to be developed during the PhD.
- The early stages of crystal nucleation and polymorph control: microfluidics and external (laser) perturbations will be used to control nucleation and study the results using modern spectroscopy and microscopy.
- Liquid-liquid phase transitions in molecular liquids: confocal fluorescence and Raman microscopy will be used to study an elusive new type of thermodynamic transition that may change our view of the liquid phase forever.
- Femtosecond dynamics in water and aqueous solutions: state-of-the-art laser spectroscopy will be used to study the weird and wonderful properties of water and its interaction with solvated molecules and proteins.
The group is highly successful with many active international academic and industrial collaborations throughout Europe, the US, and Japan. There is flexibility in the direction of your PhD project and the option of carrying out some of your research with collaborators abroad.
Requirements: Candidates must have or expect to obtain a good honours degree in chemistry, chemical physics, physics, chemical engineering, or a related degree.
For informal inquiries, please contact Klaas Wynne. For formal application please visit http://www.gla.ac.uk/colleges/scienceengineering/graduateschool/. More information on the ultrafast group at http://www.chem.gla.ac.uk/staff/wynne/ and http://www.ultrachemphys.org/. More information on the Dynamics & Structure “super” group at http://www.gla.ac.uk/schools/chemistry/research/ds/.
Ultrafast physical chemistry labs in the School of Chemistry at Glasgow University (August 2011).
TPP crystals (November 2011)
- October 2012: Dr Christopher Syme has started as a research associate in the group. He will be using confocal fluorescence microscopy and fluorescence lifetime imaging to study phase transitions in liquids.
- May 2012: Fully funded PhD studentships in the Wynne group. Applications are invited for a number of PhD studentships in the Wynne group. Some of these studentships are part of the Doctoral Training Centre (DTC) in Continuous Manufacturing and Crystallisation (CMAC).
- 9 May 2012: Our paper "The dynamic crossover in water does not require bulk water" just came out in PCCP, see doi:10.1039/c2cp40703e. In a nutshell, it shows that you only need one water molecule to have bulk water properties (as long as that water molecule can form a water pentamer).
18/4/12: The latest issue of PCCP (Physical Chemistry and Chemical Physics), the top physical chemistry journal of the Royal Society of Chemistry, is dedicated to such ultrafast chemical dynamics. The special issue was guest edited by Prof Klaas Wynne in the School of Chemistry at Glasgow University and his colleague Dr Neil Hunt at the University of Strathclyde. Special issue PCCP on Ultrafast Chemical Dynamics.
12/4/12: Glasgow University press release Funding boost for Ultrafast Chemical Physics.
- March 2012: Postdoc position in the group.See http://www.jobs.ac.uk/job/AEF581/research-associate/. Apply online at www.glasgow.ac.uk/jobs(enter Reference Number 001765). Closing date: 29 April 2012
- February 2012: The 2011 UCP meeting in Glasgow was discussed in the March 2012 issue of Nature Chemistry: Ultrafast chemical physics: In search of molecular movies. The future is ultrafast!
- December 2011: The International Workshop on Ultrafast Chemical Physics & Physical Chemistry (UCP 2011) was held in Glasgow. Photos from the UCP2011 event here.
- October 2011: The Ultrafast Chemical Physics group has won a £0.7M EPSRC grant to study liquid-liquid phase transitions using microscopy in collaboration with Chemical Engineering at Strathclyde. EPSRC grant for UCP group.
- July 2011: We would like to cordially invite you to submit a paper to a special issue of PCCP on femtosecond spectroscopy entitled "Ultrafast Chemical Dynamics". Topics that will be covered include: * ultrafast dynamics of reactions in proteins * ultrafast structure and dynamics of liquids and solutions * ultrafast chemical processes at interfaces * ultrafast dynamics of electronically excited states * ultrafast atomic structure and dynamics in the solid state. The special issue will feature a number of invited overviews followed by contributed papers. The deadline for submissions is 14 November 2011. For more information, see http://blogs.rsc.org/cp/2011/06/29/pccp-themed-issue-ultrafast-chemical-dynamics/.
- July 2011: the European Conference of Crystal Growth ECCG4 will be held 17 to 20 June 2012 in Glasgow.
- 7 July 2011: the EPSRC-funded Coherent regenerative amplifier (producing 23-fs 2.7-mJ 800-nm pulses at a repetition rate of 1 kHz) has been reinstalled in our lab again. This is in addition to a new Coherent Micra-10 (producing 15-fs 800-nm pulses at 80 MHz).
- May 2011: A Faraday Discussion on 'Mesostructure and dynamics in liquids and solution' will be held in September 2013 most likely in Bristol.The organising committee consists at the moment of Alan Soper (Rutherford Appleton Laboratory), Austen Angell (Arizona State University), Ken Seddon (Queen's Belfast), Stephen Meech (UEA), an Klaas Wynne (Glasgow University).
- May 2011:
The new ultrafast chemical physics laser lab is pretty much ready. Now all we need is some (working) femtosecond lasers...
- 16 November 2010: New website for the International Workshop on Ultrafast Chemical Physics & Physical Chemistry UCP 201.
- October 2010: Next Ultrafast Chemical Physics meeting (UCP 2011) set for 14-16 December 2011 at the University of Strathclyde. Confirmed speakers include Prof David Klug (Imperial College, multidimensional spectroscopy), Prof Andrea Cavalleri (University of Oxford, femtosecond X-ray science) and Prof Klaas Wynne (University of Glasgow, terahertz spectroscopy). In addition we have confirmed attendance of Prof Dwayne Miller (University of Toronto) as plenary speaker for the conference.
2 October 2010: Positions. A lectureship (assistant professorship) in ultrafast physical chemistry is available. The ideal candidate would be interested in ultrafast femtosecond spectroscopy of the condensed phase or an allied area. Brand new lab space will be available. Ref: 00057-10, Closing Date: 29th October 2010.
- 1 November 2010: KW's official start as chair in physical chemistry in the School of Chemistry at the University of Glasgow.
- August 2010: Our paper in JACS (described in Serving nanoparticle “soup”) has been cited 19 times on Web of Science exactly one year after its publication. It describes how using multiple spectroscopies, we discovered mesoscopic structure in room-temperature ionic liquids.
- 24 March 2010: Our paper The effects of anion and cation substitution on the ultrafast solvent dynamics of ionic liquids: A time-resolved optical Kerr-effect spectroscopic study, JCP 119, 464 (2003) was selected as highlighted reference in the JCP Spotlight Collection on ionic liquids, March 2010.
- 12 March 2010: Our paper Universal nonexponential relaxation: Complex dynamics in simple liquids was selected JChemPhys editors’ choice as one of the most innovative and influential articles in the field of Chemical Physics in 2009. See http://jcp.aip.org/jcp/editors_choices_2009.
- 5 January 2010: Our paper Universal nonexponential relaxation: Complex dynamics in simple liquids was the 3rd most downloaded paper of J. Chem. Phys. in December 2009.
- 5 August 2009: Read more about our latest paper in JACS in Serving nanoparticle "soup".
- 4 August 2009: We were joined by new postdoc Marco Candelaresi.
- May 2009: New ultrafast physical-chemistry lab is ready!
- 30/31 October 2008: The 2008 ultrafast physical-chemistry (UCP) meeting was held at Strathclyde.
- 10 July 2008: We were joined by new postdoc Kitsakorn Locharoenrat.
- 23 May 2008: Our paper "Glasslike Behavior in Aqueous Electrolyte Solutions" was selected "Editors' Choice" in the 23 May issue of the journal Science (PDF, 800kB).
- 12 May 2008: Groups wins £0.6M EPSRC grant "Two-dimensional terahertz–IR spectroscopy: a unique probe of ultrafast hydrogen-bond dynamics of liquid water and model systems" by KW, JOK, and DJSB.
- 2 May 2008: Strathclyde will host the "International Workshop on ultrafast physical-chemistry 2008 (UCP ‘08)" on 30/31 October 2008 to be held in the Senate/Court suite. Plenary speaker is Prof Robin Hochstrasser FRSE (University of Pennsylvania). Confirmed invited speakers are Prof Casey Hynes (CNRS, Paris and University of Colorado, Boulder), Prof Charles Schmuttenmaer (Yale), Prof Majed Chergui (Ecole polytechnique fédérale de Lausanne), Prof Mischa Bonn (AMOLF, Amsterdam), Prof Peter Hamm (University of Zurich), and Prof Thomas Elsaesser (Max Born Institute, Berlin). The workshop is organised by Angus J. Bain (UCL), David Klug (Imperial), Steve Meech (UEA), Neil Hunt (Strathclyde), and Klaas Wynne (Strathclyde).
- 24 April 2008: Our paper "Glasslike Behavior in Aqueous Electrolyte Solutions" came out in J. Chem. Phys. A summary of the paper in simple terms (best attempt anyway) is on the page The science of syrup and traffic jams.
- 4 March 2008: Visiting professor Robin Hochstrasser of the University of Pennsylvania has been elected Honorary Fellow of the Royal Society of Edinburgh. This is a prestigious fellowship for scientists of great international renown and we are delighted that Robin has been honoured in this way.
- 18 March 2007: New paper in JACS on terahertz spectra associated with a helix to coil transition in a peptide. Read more about it in the research highlight Observing ‘The Lubricant of Life’
- 10 January 2007: New paper on terahertz emission from nanostructured surfaces has come out in PRL. Read more about it in the research page on terahertz technology.